Insulin like growth factor-1 (Mecasermine): tried in patients with severe insulin resistance
Aldose reductase inhibitors- Alconil, Sorbinil. They prevent diabetes complications
Amylin analogue (Pramalinitide): It improve glycemic control
Incretins: GIP (glucose dependant insulinotropic polypeptide) & GLP-1 (glucagon like peptide-1) increase glucose dependant insulin secretion but rapidly metabolized by DPP IV (Dipeptidyl peptidase)
Exenatide is a GLP-I agonist that resist DPP IV & has a good glycemic control.
Sitagliptin & Vidagliptin are DPP IV inhibitors which prolong the effect of incretins
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