Monoclonal Antibodies

Both polyclonal and monoclonal antibodies against cell-surface antigens are widely used for prevention and treatment of various diseases

The advent of hybridoma technology to produce monoclonal antibodies was a major advance in immunology
Both polyclonal and monoclonal products have a place in immunosuppressive therapy
Based on origin, monoclonal antibodies may be murine, humanized, human or chimeric
Following is the list of some monoclonal antibodies

Trastuzumab- used in Ca breast

Rituximab- used in Non Hodgkins lymphoma (tu for tumour)

Infliximab- used in rheumatoid arthritis

Omalizumab- used in bronchial asthma ((li suffix for monoclonal antibodies, used in disorders of immunity)

Absciximab- used as antiplatelet antibody in thromboembolic disorders (Ci suffix for circulatory system)

Tefibazumab- for staphylococcal infections (ba suffix for bacterial disease)

Natalizumab- multiple sclerosis

Denosumab- osteoporosis (os suffix for osteoporosis)

Palivizumab- for respiratory syncitial virus infection (vi suffix for viral infection)

Daclizumab- to prevent graft rejection