Ezetimibe

Ezetimibe: inhibit intestinal absorption of cholesterol & phytosterols

Interfere with specific cholesterol transport protein in intestinal mucosa

Reduce absorption of both dietary & biliary cholesterol

Compensatory ↑ in cholesterol synthesis, which can be blocked by statins

Statins + ezetimibe: synergistic CH lowering effect

Weak hypocholestrolemic drug

no major side effects