1. Clarithromycin covers Mycobacterium avium complex (MAC), other atypical mycobacteria, M. leprae & some anaerobes.It also covers Legionella, M.pneumonae & H. pylori, while erythromycin is not active against these microbes.
2. Clarithromycin is more acid stable than erythromycin, rapidly absorbed, better gastric tolerance as compared to erythromycin
3. Clarithromycin has better tissue penetration.
4. Erythromycin is given four times a day while clarithromycin is given twice daily
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