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Sunday, July 4, 2010

How beta blocker propanolol is effective in hypertension ?

1. Reduction of cardiac output (CO) leads to reduce total peripheral resistance (TPR). Due to reduction in TPR both systolic & diastolic BP falls.
2. Decrease renin from kidney leading to decrease plasma renin activity
3. Decrease NA release from sympathetic nerves
4. Decreased central sympathetic outflow

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