TREATMENT OF TYPHOID FEVER OR ENTERIC FEVER

Typhoid fever is a systemic disease characterized by fever and abdominal pain and caused by dissemination of S. Typhi or S. Paratyphi
Diseases was initially called typhoid fever because of its clinical similarity to typhus
Typhoid fever was clearly defined pathologically as a unique illness on the basis of its association with enlarged Peyer's patches and mesenteric lymph nodes
Empirical treatment:
Ceftriaxone 1-2 g/d iv for 7-14 days
Azithromycin 1 g/d orally for 5 days
Ceftriaxone is to be preferred over FQ in children, pregnant women & in areas with FQ resistance
Fully susceptible cases:
Ciprofloxacin (First line) 500 mg BD for 5-7 days
Amoxycillin 1g TDS for 14 days
Cotrimoxazole 160/800 mg BD for 14 days
Multidrug-Resistant
Ciprofloxacin 500 mg BD (PO) for 5–7 days
Ceftriaxone 2–3 g/d (IV) for 7–14 days
Azithromycin 1 g/d (PO) for 5 days