OTHER FLUOROQUINOLONES

Pefloxacin:
Methyl derivative of Norfloxacin
Preferred for meningeal infections
Ofloxacin:
More potent than ciprofloxacin for gram +ve & anaerobes
Also inhibit M. tuberculosis & M.leprae
Levofloxacin:
Levoisomer of of ofloxacin
Improved activity against S. pneumonae & other gram positive bacteria
Oral BA is 100 %
Indications are CA pneumonia, exacerbation of chronic bronchitis & ENT infections
Lomefloxacin:
Second generation FQ, more active against gram positive
Long half life
Sparfloxacin:
Second generation FQ
Indications are pneumonia, exacerbations of bronchitis, ENT infections, chlamydial infections
Good efficacy in TB, MAC infections in AIDS pts & leprosy
Phototoxic reactions, slight prolongations of QTc interval
Gatifloxacin:
2nd generation FQ
Indications are pneumonia, exacerbations of bronchitis, URTI & LRTI
ADR: Tachycardia, prolong QTc interval, Torsades de pointes
Discontinued in USA & UK
Drugs that prolong QTc interval are cisapride, TCA, phenothiazines class IA & III antiarrhythmics
Moxifloxacin:
2n d generation FQ
Most potent FQ against M. tuberculosis
Also prolong QTc interval
Indications are same as that of other 2nd gen. FQ