BETA LACTAM ANTIBIOTICS

Antibiotics having beta lactam ring
These include penicillins, cephalosporin, monobactam & carbapenem
Penicillin nucleus consist of fused thiazolidine & beta lactam rings to which side chains are attached through an amide linkage
Penicillin G (PnG) having a benzyl side chain is the original penicillin used clinically
The side chain of natural Pn can be split of by an amidase to produce 6 amino penicillanic acid. Other side chains can be attached to it resulting in different type of semisynthetic Pn
Mechanism of action: Beta lactam antibiotic interfere with the synthesis of bacterial cell wall
Bacterial cell wall is made up of Peptidoglycan
Peptidoglycan is composed of N acetylmuramic acid (NAM) & acetylglucosamine (NAG) which are cross linked with each other
This cross linking occurs with the help of enzyme transpeptidase
Beta lactam antibiotic inhibit the enzyme transpeptidase so that cross linking does not occur
This enzyme transpeptidase & other related proteins constitute the penicillin binding protein
This cross linking occurs with the help of enzyme transpeptidase
Beta lactam antibiotic inhibit the enzyme transpeptidase so that cross linking does not occur
This enzyme transpeptidase & other related proteins constitute the penicillin binding protein
This cross linking occurs with the help of enzyme transpeptidase
Beta lactam antibiotic inhibit the enzyme transpeptidase so that cross linking does not occur
This enzyme transpeptidase & other related proteins constitute the penicillin binding protein
This cross linking occurs with the help of enzyme transpeptidase
Beta lactam antibiotic inhibit the enzyme transpeptidase so that cross linking does not occur
This enzyme transpeptidase & other related proteins constitute the penicillin binding protein