Sildenafil

(By Dr. Ahmad Najmi, Index Medical College, Indore)


1.It is used in erectile dysfunction
2. Inhibits (phosphodiesterase -5 ) PDE5 in the corpus cavernosa of the penis, thus increasing the level of c-AMP
3. 50mg, per orally 1 h before sexual activity
4. potentiate nitrate’s hypotension activity
5. ketoconazole & erythromycin increases its level
6. renal & hepatic disease increases its level
7. Side effects:

headache, flushing, dyspepsia, myalgia