Monoamine oxidase Inhibitors

Monoamine oxidase enzyme is present in liver, intestines & MA releasing neurons
Inactivates monoamines
Inactivates dietary tyramine in liver
Foods rich in tyramine: cheese & red wine
Nonselective MAOI: e.g. Phenelzine & tranylcypromine, not used now a days because of frequent side effects & drug interactions
Selective MAOAI: Moclobemide, Clorgiline: used in depression
Selective MAOBI: Selegiline, used in parkinsonism