Antiinflammatory property of Macrolides

In addition to their antiinfective properties, some macrolides possess immunomodulatory effects. These macrolides have been used successfully to treat diffuse panbronchiolitis, a progressive inflamatory disease and may be very useful in the treatment of asthma, ,chronic bronchitis, chronic sinusitis, nasal polyps, ottitis media & bronchiectasis.Macrolide antibiotics down-regulate damaging prolonged inflammation as well as increase mucus clearance, decrease bacterial virulence and prevent biofilm formation.