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Saturday, November 14, 2009

EPILEPSY

Epilepsy is a tendency of recurrent fits. It oocurs due to abnormal electrical activity in neurones. The causes of epilepsy are:
Idiopathic
Secondary causes like trauma, tuberculosis, tumour, infection etc
Clinically epilesies can be classified into following groups
Grandmal epilepsy or generalized tonic clonnic
Petitmal epilepsy or absense seizure
Myoclonic epilepsy
Atonic epilepsy
Infantile epilepsy
Simple partial seizures
Complex partial seizures
Epilepsies can also be induced experimentally in animals by giving electric shock or giving some chemicals like PTZ. This is used in the screening of antiepileptic drugs
The drugs used in epilepsies are phenytoin, carbamazepine, sodium valproate, gabapentin, Tiagabin, Vigabatrine, Lamotrigine & benzodiazepines like diazepam, lorazepam & midazolam

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